Wiang Boonmee, 63, developed bizarre growths across her face as a child.
They spread across her face making her go blind and twisting and deforming her nose and mouth.
After several decades the unsightly growths started to droop from her face — giving it the appearance that it's melting.
The condition is believed to be a severe disease related to the genetic condition neurofibromatosis.
VIRAL PRESSDISFIGURED: Thai woman Wiang Boonmee has a rare disease that makes it seem her face is melting
She recently moved from her home in rural Surin province in Thailand to the capital Bangkok, and scrapes a living selling flowers and camphor oils from a pavement stall.
Her condition came to national attention after medics were contacted to help her.
But now she refuses to have treatment.
Wiang, a mum-of-one and grandma-of-two, told local media: "I have had this problem for a long time. More than I can remember.
VIRAL PRESSTRAGIC: The grandma has been sent blind by the condition that causes abnormal face growths
"I have survived and I'm healthy and have a job."
She said she is afraid of having surgery at her age.
"If I have an operation I might never wake up. I'm afraid I would not survive it."
A local woman Praew Wattana, 22, was shocked by Wiang's plight and contacted health workers.
VIRAL PRESSFRIGHTENED: The woman refuses to have surgery in case she dies during it
She said she had asked the grandma about her condition, and that she did not beg for anything.
"I'd really like to see her receive help," she said.
Dr Sunura Ourairat, President of Rangsit University, visited Wiang on the street on Friday to offer to get her face seen to.
"We are welcome and ready to help with surgery but she is afraid of dying," he said.
"She said thank you to everybody for trying to help. We will continue to see what can be done for her."
Neurofibromatosis often starts in childhood and causes tumours to grow on the nerve tissue.
Its severity depends on the sufferer and usually in the developed world it is treated in the early stages with surgery, which Wiang may well have not had access to in rural Thailand.
This week two parents spoke of their heartbreak after a rare condition caused their baby boy's head to swell to three times its natural size.